장선영Sun-Young Chang
Mar. 2004- Jun. 2004 Post-doctoral fellow Seoul National University Jul. 2004- Nov. 2008 Post-doctoral fellow International Vaccine Institute Dec. 2008- Sep. 2009 Post-doctoral fellow Harvard Medical School/BWH Oct. 2009-Aug. 2010 Post-doctoral fellow Harvard Medical School/MGH Sep. 2010-Feb. 2012 Research Scientist International Vaccine Institute Mar. 2012-Present Professor College of Pharmacy, Ajou University
General interests: “Mucosal Immunology and Host Defense” We are interested in the immune regulation mechanism observed in the mucosal tissues which is called mucosal immunology. Mucosal tissues including gastrointestinal tract, respiratory tract and urogenital tract were exposed to external environment, colonized commensal microbes and serve as an infection route of pathogen. These tissues have established complex and elegant immune system to regulate immunity via immune tolerance to commensal microbes versus to induce strong protective immunity against invading pathogen. Therefore, mucosal immune system is distinct with sterile systemic immune system and developed their unique system. To reveal the puzzling immunological network in these tissues, we are focused on the study for the function of antigen presenting cell group, especially dendritic cells (DCs). In addition, we also have interests about the cross-talk between sterile systemic and mucosal system under disease condition, dendritic cell conditioning under specialized microenvironments, interaction between commensal microbes and immune system and infectious disease including development of vaccines.